2,558 research outputs found
On "jamitons," self-sustained nonlinear traffic waves
"Phantom jams," traffic blockages that arise without apparent cause, have
long frustrated transportation scientists. Herein, we draw a novel homology
between phantom jams and a related class of self-sustained transonic waves,
namely detonations. Through this analogy, we describe the jam structure;
favorable agreement with reported measurements from congested highways is
observed. Complementary numerical simulations offer insights into the jams'
development. Our results identify conditions likely to result in a dangerous
concentration of vehicles and thereby lend guidance in traffic control and
roadway design.Comment: 6 pages, 4 figure
A myofibrillar protein of insect muscle related to vertebrate titin connects Z band and A band: Purification and molecular characterization of invertebrate mini-titin.
We show that myofibrils of insect flight and leg muscle contain a doublet of polypeptides with apparent molecular weights of 700K (K = 10(3) Mr) (Hmp I) and 600K (Hmp II), respectively. In Locusta migratoria high ionic strength extraction solubilizes only Hmp II, which is readily purified in native form. It probably reflects a proteolytic derivative of the non-extractable Hmp I. On the basis of its viscosity radius and sedimentation coefficient, Hmp II has a molecular weight of 600K and seems to consist of a single polypeptide chain. The highly asymmetric structure of the molecule is confirmed by rotary shadowing. The flexible rods have a uniform diameter of 3–4 nm and an average length of 260 nm. Polyclonal antibodies show cross-reactivity between Hmp II and its putative precursor Hmp I. We discuss the similarities and differences between the larger titin I/titin II of vertebrate sarcomeric muscle and the smaller Hmp I/Hmp II of invertebrate muscle and conclude that the latter may reflect a mini-titin. In line with the smaller length, immunoelectron microscopy locates the insect mini-titin to the I band and a very short portion of the A band only, while vertebrate titin is known to connect the Z band to the M band. Mini-titin has also been purified from several other insects including Drosophila. Immunofluorescence microscopy on frozen sections shows that mini-titin is present in the sarcomeric muscles of various species from different invertebrate phyla. These include Annelida, Nematomorpha, Plathelmintha, Nemertea and Nematoda like Ascaris lumbricoides and Caenorhabditis elegans. This wide-spread occurrence of invertebrate mini-titin is confirmed by immunoblotting experiments
A Variational Monte Carlo Study of the Current Carried by a Quasiparticle
With the use of Gutzwiller-projected variational states, we study the
renormalization of the current carried by the quasiparticles in
high-temperature superconductors and of the quasiparticle spectral weight. The
renormalization coefficients are computed by the variational Monte Carlo
technique, under the assumption that quasiparticle excitations may be described
by Gutzwiller-projected BCS quasiparticles. We find that the current
renormalization coefficient decreases with decreasing doping and tends to zero
at zero doping. The quasiparticle spectral weight Z_+ for adding an electron
shows an interesting structure in k space, which corresponds to a depression of
the occupation number k just outside the Fermi surface. The perturbative
corrections to those quantities in the Hubbard model are also discussed.Comment: 9 pages, 9 figure
Axo-glial interdependance in peripheral nerve development
During the development of the peripheral nervous system, axons and myelinating Schwann cells form a unique symbiotic unit, which is realized by a finely tuned network of molecular signals and reciprocal interactions. The importance of this complex interplay becomes evident after injury or in diseases in which aspects of axo-glial interaction are perturbed. This Review focuses on the specific interdependence of axons and Schwann cells in peripheral nerve development that enables axonal outgrowth, Schwann cell lineage progression, radial sorting and, finally, formation and maintenance of the myelin sheath
Vesuvio civil protection exercise MESIMEX: survey on volcanic risk perception.
In October 2006 the European Civil Protection Exercise MESIMEX
(Somma Vesuvio Mesimex – Major Emergency SIMulation Exercise) on
volcanic risk took place at Vesuvio, promoted by Campania Region and
coordinated by the Italian Civil Protection Department. The exercise was
focused on the preparedness phase for a major volcanic emergency in the
area of Vesuvio. An evacuation of a sample of 1800 inhabitants from the
Vesuvio Red Zone was also tested during the drill because the emergency
plan ensures the complete evacuation of the population from the higher
risk zone before the onset of the eruption. During that event a survey on
volcanic risk perception was carried out on the evacuated population in
order to compare the results with the ones coming from a previous similar
survey, using the same questionnaire, carried out on a wider sample
of residents in the Vesuvio Red Zone few months before MESIMEX exercise.
The aim was to point out any differences in population’s attitude towards
volcanic risk after having received detailed information on the
emergency plan and on the hazards and risk related to the reactivation of
Vesuvio, and experiencing the exercise. 463 questionnaires were distributed
to the population evacuated from the 18 municipalities of the Red
Zone and participating to the exercise. Main results in comparing data
from MESIMEX survey with the Vesuvio previous one, put in evidence
how the general level of Vesuvio residents’ trust remains quite low, indicating
that a continuous and effective effort has to be done by both scientific
community and Civil Protection Department. Particular attention
should be paid in education and outreach activities and in involving people
in risk mitigation procedures, also through more frequent exercises
Repetitive titin epitopes with a 42 nm spacing coincide in relative position with known A band striations also identified by major myosin-associated proteins. An immunoelectron-microscopical study on myofibrils.
A direct titin-thick filament interaction in certain regions of the A band is suggested by results using four new monoclonal antibodies specific for titin in immunoelectron microscopy. Antibodies T30, T31 and T32 identify quasi-repeats in the titin molecule characterized by a 42–43 nm repeat spacing. These stripes seem to coincide with striations established by others on negatively stained cryosections of the A band. Antibodies T30 and T32 recognize epitopes matching five or two of the seven striations per half sacromere known to harbor both the myosin-associated C-protein and an 86K (K = 10(3) Mr) protein. Antibody T31 labels two stripes in the P zone, which correspond to the two positions where decoration is seen with 86K protein, but not with C-protein. The single titin epitope defined by antibody T33 is located 55 nm prior to the center of the M band. This position seems to coincide with the M7 striation defined by others on negatively stained A bands. The T33 epitope position proves that the titin molecule, which is known to be anchored at the Z line, also penetrates into the complex architecture of the M band. The titin epitopes described here enable us to begin to correlate known ultrastructural aspects of the interior part of the A band with the disposition of the titin molecule in the sarcomere. They raise the question of whether there is a regular interaction pattern between titin and the thick filaments
A Correction Function Method for Poisson problems with interface jump conditions
In this paper we present a method to treat interface jump conditions for constant coefficients Poisson problems that allows the use of standard “black box” solvers, without compromising accuracy. The basic idea of the new approach is similar to the Ghost Fluid Method (GFM). The GFM relies on corrections applied on nodes located across the interface for discretization stencils that straddle the interface. If the corrections are solution-independent, they can be moved to the right-hand-side (RHS) of the equations, producing a problem with the same linear system as if there were no jumps, only with a different RHS. However, achieving high accuracy is very hard (if not impossible) with the “standard” approaches used to compute the GFM correction terms.
In this paper we generalize the GFM correction terms to a correction function, defined on a band around the interface. This function is then shown to be characterized as the solution to a PDE, with appropriate boundary conditions. This PDE can, in principle, be solved to any desired order of accuracy. As an example, we apply this new method to devise a 4th order accurate scheme for the constant coefficients Poisson equation with discontinuities in 2D. This scheme is based on (i) the standard 9-point stencil discretization of the Poisson equation, (ii) a representation of the correction function in terms of bicubics, and (iii) a solution of the correction function PDE by a least squares minimization. Several applications of the method are presented to illustrate its robustness dealing with a variety of interface geometries, its capability to capture sharp discontinuities, and its high convergence rate.National Science Foundation (U.S.) (Grant DMS-0813648)Brazil. Coordenacao de Aperfeicoamento de Pessoal de Nivel SuperiorFulbright Program (Grant BEX 2784/06-8
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